In this session, we will delve into the crucial role of Geographic Information Systems (GIS) and location in creating Digital Twins. As the backbone of Digital Twins, GIS provides a robust framework for integrating spatial data, enabling real-time data synchronization, reality capture, and advanced capabilities like ArcGIS Knowledge and GeoAI. Join us as we explore the foundational architecture required to construct Digital Twins, harness the potential of real-time data, and utilize cutting-edge GeoAI technologies to unlock valuable insights and drive informed decision-making.